1 Then the Lord said unto Moses, Go in unto Pharaoh, and tell him, Thus saith the Lord God of the Hebrews, Let my people go, that they may serve me.

2 For if thou refuse to let them go, and wilt hold them still,

3 Behold, the hand of the Lord is upon thy cattle which is in the field, upon the horses, upon the asses, upon the camels, upon the oxen, and upon the sheep: there shall be a very grievous murrain.

4 And the Lord shall sever between the cattle of Israel and the cattle of Egypt: and there shall nothing die of all that is the children’s of Israel.

Moses came to deliver God’s next promised plague to Pharaoh, and more than any of the previous it was going to cause real, irreparable harm. For the first time, God would bring a plague that would directly cause death. The death was not to be upon the people—that was still to come—but upon the Egyptian livestock. The death would come in the form of a “murrain,” which is an infectious disease. Many types of animals would be afflicted, but most notably the cattle and the sheep.

These, as has been previously discussed, were likely sacred animals to the Egyptians. So this plague was not only to destroy their beasts of burden and their meat supply, but also an assault against their very religion! God is a God of truth, and He does not show respect to the falsely “sacred” rituals that man invents. By destroying the cattle and the sheep God was not only emphasizing His superiority over the Egyptian people, but also over their gods. It might have been deeply offensive to the Egyptians, but what were they to do about it? It was up to their gods to defend themselves against other divinities, and apparently they could not!

Also note that God once again established a divide between the land of Egypt and Goshen. God promised that “there shall nothing die” of the Israelites. Thus, His people would be free to continue raising, sacrificing, and consuming the very same animals that the Egyptians held most dear!