Then saith the woman of Samaria unto him, How is it that thou, being a Jew, askest drink of me, which am a woman of Samaria? for the Jews have no dealings with the Samaritans.
Jesus answered and said unto her, If thou knewest the gift of God, and who it is that saith to thee, Give me to drink; thou wouldest have asked of him, and he would have given thee living water.

And the presence of God withdrew from Moses, that his glory was not upon Moses; and Moses was left unto himself. And as he was left unto himself, he fell unto the earth.
And it came to pass that it was for the space of many hours before Moses did again receive his natural strength like unto man; and he said unto himself: Now, for this cause I know that man is nothing, which thing I never had supposed.

COMMENTARY

How is it that thou askest drink of me? for the Jews have no dealings with the Samaritans
The woman at the well had an understood reality: that Jews hated the Samaritans, and would have nothing to do with them. Thus her confusion when that reality was disrupted by Christ’s willingness to converse with her.
However this was just the beginning of the new realities that she was about to become acquainted with. For as we see in the next verse, Jesus then began to open her mind to the notion of living water. This is a reality that she struggles with initially, confusing it with a literal water, and not a spiritual nourishment. Bit-by-bit Jesus has to guide her through the first steps into this strange new world.

Now, for this cause I know that man is nothing, which thing I never had supposed
After his encounter with the Lord, Moses found his reality disrupted as well. Each of us is by default well acquainted with the reality of earth life, in which man is the highest form of existence. And while the reality of earth life is real, it is not the only reality that is real. There is also a heaven, a God, and in that broader reality man is a very small thing indeed.
Like the woman at the well, stepping into the greater reality might be awkward at first. Like Moses, we might find that doing so requires accepting uncomfortable facts, such as our own nothingness. But the greater reality is real and it is greater. It is only to our own benefit that we make the transition.